Q. Are 501(c)(3) organizations permitted to

conduct activities or provide grants outside the U.S.?​

A. Yes.  Activities that are charitable within the meaning of section 501(c)(3) when carried on within the United States also qualify for exempt status under 501(c)(3) when carried on in foreign countries.

Organizations making foreign grants, however, must show that the applicant is not controlled by, or otherwise obligated to transfer donations to, any foreign entity.  (Note that rules for private foundations, not covered here, are somewhat different.)